Can antidepressants stop you from having an orgasm?

Some can. Difficulty reaching orgasm is a well-known side effect of certain antidepressants, particularly SSRIs. Don't stop or adjust your medication on your own, as that can be risky. Talk to your prescriber instead; they may be able to review the dose, timing or type of medication. Depression itself can also affect desire and arousal, so it's worth discussing both.